Wednesday, October 11, 2006

Honey as medicine for MRSA, and in general

Significance of honey as medicine, medicinal values of honey.
MRSA: Methicillin-resistant Staphylococcus aureus (MRSA) infection.
Wikipedia says:
Methicillin-resistant Staphylococcus aureus (MRSA) is a specific strain of the Staphylococcus aureus bacterium that has developed antibiotic resistance to all penicillins, including methicillin and other narrow-spectrum β-lactamase-resistant penicillin antibiotics.[1] MRSA was first discovered in the UK in 1961 and is now widespread, particularly in the hospital setting where it is commonly termed a superbug.

A recent article in Wired in describes :
Honey, formed when bees swallow, digest and regurgitate nectar, contains approximately 600 compounds, depending on the type of flower and bee. Leptospermum honeys are renowned for their efficacy and dominate the commercial market, though scientists aren't totally sure why they work.

"All honey is antibacterial, because the bees add an enzyme that makes hydrogen peroxide," said Peter Molan, director of the Honey Research Unit at the University of Waikato in New Zealand. "But we still haven't managed to identify the active components. All we know is (the honey) works on an extremely broad spectrum."

Attempts in the lab to induce a bacterial resistance to honey have failed, Molan and Simon said. Honey's complex attack, they said, might make adaptation impossible.

The International Journal of Lower Extremity Wounds states in its preface of a study:
Some clinicians are under the impression that there is little or no evidence to support the use of honey as a wound dressing. To allow sound decisions to be made, this seminar article has covered the various reports that have been published on the clinical usage of honey. Positive findings on honey in wound care have been reported from 17 randomized controlled trials involving a total of 1965 participants, and 5 clinical trials of other forms involving 97 participants treated with honey. The effectiveness of honey in assisting wound healing has also been demonstrated in 16 trials on a total of 533 wounds on experimental animals. There is also a large amount of evidence in the form of case studies that have been reported. It has been shown to give good results on a very wide range of types of wound. It is therefore mystifying that there appears to be a lack of universal acceptance of honey as a wound dressing. It is recommended that clinicians should look for the clinical evidence that exists to support the use of other wound care products to compare with the evidence that exists for honey.

Which shows , things are still not final. Wait!

Joe Kissell writes:

When I get a sore throat, I always find a cup of tea with some honey very soothing. But thanks to my proper Western scientific conditioning, I always assumed that the restorative power of honey was mostly in my head. Sure, it tastes good and has a pleasant texture that coats my irritated throat, but it’s practically pure sugar, after all. What good could it possibly do me other than diminishing my perception of discomfort for a few minutes? So I’ve been content in my belief that honey is little more than a tasty placebo. Now, ironically enough, my convictions are being challenged, as researchers are turning up new evidence of honey’s medical benefits left and right.

Historically, honey has been used as a folk remedy in cultures around the world for millennia. It has been prescribed informally as a cure for smallpox, baldness, eye diseases, and indigestion. It’s even been used as a contraceptive. As with most natural “cures” unsupported by scientific studies, I sort of chuckle and sigh when I read about things like this—honey may be a silly substitute for real medicine, but at least it’s not bloodletting. However, in this case, the bees may have the last laugh. It turns out that honey’s properties make it a surprisingly effective cure-all. Or, let’s say, cure-much.

Bee Fruitful and Multiply
Honey’s salutary effects stem primarily from its antimicrobial properties. Most bacteria and other microorganisms cannot grow or reproduce in honey. I found this quite surprising, because all things being equal, bacteria love sugar. Honey contains around 40% fructose and 30% glucose—among other sugars—making it seemingly a great treat for microbes. However, honey is also somewhat acidic, and acids prevent the growth of some bacteria. More importantly, honey does not provide the water and oxygen needed to support bacterial growth. Although honey contains a fair amount of water, it’s supersaturated with sugar—meaning the water is not available to the microorganisms.

So what happens when you dilute honey with water—the bacteria just multiply like crazy, right? Well…yes and no. Amazingly enough, diluted honey supports the growth of bacteria that are helpful to humans while killing off dangerous strains. Some microorganisms do indeed flourish in a dilute solution of honey—such as the yeast used to ferment it into mead. Also, certain types of beneficial bacteria that live in the human intestines and aid digestion do well in a mixture of honey and water. But honey also contains a substance called glucose oxidase. When combined with water and oxygen, glucose oxidase forms gluconic acid and hydrogen peroxide—the very same stuff you probably have in your medicine cabinet right now. This means that diluted honey can serve as an excellent antiseptic, while being far less likely than ordinary hydrogen peroxide to harm already-damaged tissue.

Show Me the Honey
What does all this mean in practical terms? For one thing, it means that honey applied topically to a wound can promote healing just as well as, or in many cases better than, conventional ointments and dressings. Its antibacterial properties prevent infection. It also functions as an anti-inflammatory agent, reducing both swelling and pain. As if that weren’t enough, it even reduces scarring. In studies around the world, honey has been shown to be extraordinarily effective in the treatment of wounds, burns, and surgical incisions. Honey also functions as a moisturizer, making it a useful treatment for sunburn as well as a general-purpose skin softener.

But wait, there’s more! Honey is truly a head-to-toe cure. Honey has been shown to be effective in treating inflammation of the eyelid, some types of conjunctivitis, and keratitis (along with other forms of corneal damage). It can also, believe it or not, be used to treat athlete’s foot and other fungal infections.

A Spoonful of Sugar Is the Medicine
Lest you think that honey is only healthy if used on the outside of the body, it can help with a great many internal problems too. Thanks to its antimicrobial action, it not only soothes sore throats but can also kill the bacteria that sometimes cause them. Although research is inconclusive so far, there’s also the suggestion it could actually reduce tooth decay—all that sticky sugar notwithstanding. Moving down the esophagus and through the digestive tract, honey can help to heal ulcers and upset stomachs. It has also been proven to regulate intestinal function, alleviating both constipation and diarrhea. (In a similarly syzygial way, honey can be used both as a sleep aid and to increase alertness.) Honey also contains a variety of antioxidants, which may reduce the risk of cardiovascular disease and cancer.

Manuka honey, made from the flowers of the Manuka bush (Leptospermum scoparium), comes from New Zealand. Some varieties of Manuka honey contain an antibacterial component called UMF (Unique Manuka Factor), which has been found to be even more useful than ordinary honey in combating infections. Intriguingly, honey with UMF is even effective against many so-called “superbugs”—strains of bacteria such as Staphylococcus aureus that are resistant to multiple types of antibiotics. An Australian company called Medihoney has obtained the blessing of the Therapeutic Goods Administration (comparable to the U.S. Food and Drug Administration) to sell this type of honey packaged as a dressing for wounds. The company also sells honey and honey-based products designed to treat digestive problems, oral irritations and sore throats, and even skin conditions such as psoriasis.

The Color of Honey
Now that you’ve worked yourself into a gleeful frenzy over the miraculous properties of honey, I want to temper your enthusiasm a bit. The bad news, if you can call it that, is that not all honey is created equal. The chemical composition of honey depends on a huge number of variables, the most important of which is the type or types of plant that provided the source nectar. Honeys vary not only in color and flavor, but in their medicinal properties, with some varieties being much more potent than others. Because it’s impossible to regulate the comings and goings of millions of bees, there’s also no way to guarantee that honey from any location will be chemically the same from year to year or free of contamination from pollutants the bees may have found their way into. Honey supplies must be tested thoroughly and regularly.

I should mention one other caveat: never feed honey to a child under one year of age. Honey sometimes contains Clostridium botulinum spores. Although they’re inactive in the honey itself, once inside a digestive tract they can multiply and cause a potentially fatal disease of the nervous system called infant botulism. By the time of a child’s first birthday, there are usually enough beneficial bacteria in the digestive tract to make it an inhospitable environment for Clostridium botulinum, meaning that honey can be eaten safely.

As I was reflecting on all the health benefits of honey, it suddenly occurred to me: I don’t think I’ve ever seen a sick bee. Coincidence? Probably. But honey may be one miracle cure that lives up to the buzz.

The International Journal of Lower Extremity Wounds
Wikipedia [wiki. may not be accurate]
Joe Kissell 's entry:

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